Background: Insulin resistance (IR), as a result of unhealthy lifeâÂ?Â?styles and westernization, most likely contributes to the increased incidence of metabolic abnormalities and consequently, the development of metabolic syndrome (MS). Aim: The present study was undertaken to determine the magnitude of IR and associated clinicoâÂ?Â?metabolic risk factors among the outâÂ?Â?patients of a tertiary care hospital in Bihar, India. Subjects and Methods: Anthropometric profile, lipid profile, fasting blood glucose, CâÂ?Â?reactive protein (CRP) and CâÂ?Â?peptide of 112 individuals were measured using the standard procedures. IR was assessed using the homeostasis model (Homeostatic model assessment [HOMA]âÂ?Â?IR). Results: The mean IR was 1.5 (1.0). Individuals with MS, higher body mass index and CRP ≥6 mg/l had higher IR. Linear regression showed, among the components of MS, waist circumference had the highest contribution toward IR. The optimal cutâÂ?Â?off value to detect IR by HOMA2âÂ?Â?IR was 1.35. Conclusion: IR was found to have a strong association with various clinicoâÂ?Â?metabolic risk factors.
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The Annals of Medical and Health Sciences Research is a bi-monthly multidisciplinary medical journal.