Background: Since there is no diseaseâÂ?Â?specific instrument for measuring qualityâÂ?Â?ofâÂ?Â?life (QOL) in Ostomy patients in Persian language. Aim: This study was designed to translate and evaluate the validity and reliability of City of HopeâÂ?Â?quality of lifeâÂ?Â?Ostomy questionnaire (COHâÂ?Â?QOLâÂ?Â?Ostomy questionnaire). Subjects and Methods: This study was designed as crossâÂ?Â?sectional study. Reliability of the subscales and the summary scores were demonstrated by intraâÂ?Â?class correlation coefficients. Pearson’s correlations of an item with its own scale and other scales were calculated to evaluated convergent and discriminant validity. Clinical validity was also evaluated by knownâÂ?Â?group comparisons. Results: Cronbach’s alpha coefficient for all subscales was about 0.70 or higher. Results of interscale correlation were satisfactory and each subscale only measured a single and specified trait. All subscales met the standards of convergent and discriminant validity. Known group comparison analysis showed significant differences in social and spiritual wellâÂ?Â?being. Conclusion: The findings confirmed the reliability and validity of Persian version of COHâÂ?Â?QOLâÂ?Â?Ostomy questionnaire. The instrument was also well received by the Iranian patients. It can be considered as a valuable instrument to assess the different aspects of health related qualityâÂ?Â?ofâÂ?Â?life in Ostomy patients and used in clinical research in the future.
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