Adilbay Esimbetov

Department of Veterinary, Nukus Branch of the Samarkand Institute of Veterinary Medicine, Nukus, Uzbekistan

Publications

• Research Article   
  Characteristic of the Vincanine Relaxing Action on the Contractive Activity of Aortic Smooth Muscle Cells
  Author(s): Yulduzkhon Mirzayeva*, Pulat Usmanov, Sirojiddin Omonturdiev, Adilbay Esimbetov, Shakhobiddin Adizov and Bobomurod Khandamov
  
  Background & Aim: The special attention is paid to natural biologically active compounds of plant origin, which have a wide range of pharmacological effects and specifically interact with various types of ion channels. The relaxant effect of some diterpenoid alkaloids on the Ca channels of smooth muscle cells has been studied. The aim of this work was to study the mechanism of the relaxant effect of vincanine. Methods: Isolated preparations of smooth muscle segments of the aorta of white outbred rats (200 g-250 g) were used. The prepared aortic segment was placed into a special experimental chamber with a volume of 5 ml, where it was fixed with a silver wire between the rod of an electromechanical transducer (FT.03, Grass, USA). The contractile activity of the aorta preparations was recorded using a PIIT amplifier (Grass, USA) and an End.. Read More»