Original Article
Serum Levels of Interleukin-1β and Interferon-γ in Hansen’s disease
Author(s):
Amul K Butti, Shakti Kumar Yadav, Alekh Verma, V K Khurana, Sanjay Jain, Sompal Singh and Namrata Sarin*
Background: Hansen’s disease is a chronic infectious granulomatous disease caused by Mycobacterium leprae. In leprosy the final immune response depends on predominant effector pathway M. leprae bacilli are presented by antigen presenting cells to CD4+T cells with subsequent release of Interleukin -12 leading to TH1 response. Release of interferon gamma (IF-γ) promotes further TH1 response development. IF-γ along with tumor necrosis factor and IL-2 leads to recruitment of monocytes and their transformation into epithelioid cells and granuloma formation. Aims: Our aim of the study was to analyse serum levels of interleukin-1β (IL-1β) and interferon-γ in newly diagnosed untreated patients of leprosy and to co relate their levels with clinico-histopathological profile. Methods:.. Read More»
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The Annals of Medical and Health Sciences Research is a bi-monthly multidisciplinary medical journal.