Original Article
Relationship between Patients with Chronic Obstructive Pulmonary Disease and Serum S100B Protein
Author(s):
Mohammad Davood Sharifi, Alireza Movahedan, Behrang Rezvani Kakhki, Seyed Mohammad Mousavi, Koorosh Ahmadi, Mahsa Moosavi and Amir Masoud Hashemian*
Background: Chronic obstructive pulmonary disease (COPD) is a common cause of death and disability worldwide. Brain hypoxia due to acute COPD exacerbation or in chronic course of disease can affect the central nervous system and lead to behavioral and cognitive dysfunction. In addition, hypoxia causes brain injury which increases the serum biomarker of S100B protein excreted from astrocytes. The aim of the study was to assess the effect of hypoxia following COPD exacerbation on the brain by measuring the S100B. Methods: Our study consisted of group of COPD patients. These groups had 80 peoples. The serum S100B protein levels of COPD patients who were admitted to the emergency department of a teaching Hospital were measured by the ELISA method, and their correlation with other clinical and laboratory parameters was assessed.. Read More»
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The Annals of Medical and Health Sciences Research is a bi-monthly multidisciplinary medical journal.