Chibueze Peter Ihekwereme

Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Agulu, Nnamdi Azikiwe University, Awka, Nigeria

Publications

• Original Article   
  Pleurotus ostreatus extract Enhances the Phagocytic Actions of Neutrophils against Streptococcus pneumoniae
  Author(s): Angus Nnamdi Oli, Angus Nnamdi Oli*, Akunna Perpetual Emeruwa, Obinna Ikechukwu Ekwunife, Ebele Linda Okoye, Chinekwu S. Anyaoku, Gordon C. Ibeanu, Ejeatuluchukwu Obi, Chibueze Peter Ihekwereme and Monday Obaji
  
  Introduction: Edible mushrooms have played prominent roles in improving the health of people for centuries. Pleurotus ostreatus is an edible mushroom with history of medicinal uses. This study was designed to examine, in vitro and in vivo, the possibility of methanolic and hot aqueous extracts of the mushroom modulating Streptococcus pneumoniae infection. Methods: Bioactive constituents of the methanolic and hot aqueous extracts were determined quantitatively and qualitatively using standard methods. Isolation, identification and confirmation of Streptococcus pneumoniae in infected blood were done using standard protocols. The effect of the extract on cellular immune responses was assessed by phagocytosis evaluation and quantitative Nitroblue Tetrazolium Test. In vivo immunological response agains.. Read More»