Research Article
Comparative Evaluation of Salivary IgA, Flow Rate, pH and Antioxidant Capacity in Children with β-Thalassemia and Healthy Children
Author(s):
Daneswari Velagala*, N.Venugopal Reddy, Pathuri venkata sonika reddy, M. Ajay Reddy, Rajesh Garge and Chavva Hema
Thalassemia is a prevalent genetic hemoglobin disorder, particularly significant in South East Asia and Africa, with India reporting a prevalence of approximately 3.3%. Children with betathalassemia major require regular blood transfusions, which lead to complications, including iron overload and damage to various organs, including salivary glands. This study examines salivary parameters, including secretory immunoglobulin A (sIgA), pH, buffer capacity, flow rate and total antioxidant capacity, in children aged 5-12 years diagnosed with beta-thalassemia major, compared to healthy controls. A total of 40 children with beta-thalassemia and 40 healthy age- and sex-matched controls were studied. Results indicated significantly lower mean levels of salivary IgA (156.07 ± 30.27 vs. 184.20 ± 33.25), pH (6.42 ± 0.17 vs. 7.00 ± 0.13), buffer capaci.. Read More»
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