Darius Bulus

Department of Analytical Chemistry, National Agency for Food and Drug Administration and Control (NAFDAC), Kaduna, Kaduna State, Nigeria

Publications

• Research Article   
  Quantitative Assessment of the Active Ingredient of Artemether Injection Products Before and After Induced Degradation
  Author(s): Darius Bulus*
  
  The induced degradation profile of artemether injection products was accomplished with chromatographic separation using C18 column (25 cm × 4.6 mm) material 5 μm size with mobile phase combination of acetonitrile and water in the ratio of 62:38, a flow rate of 1.5 mL/min, and detection wavelength of 216 nm. The regression equation was found to be y=2.026 × +0.177 with R^2 value of 0.9976, and an accuracy of 0.42% RSD. The assay specification limit for interday precision was found to be 1.26% RSD while the intra-day was 0.83% RSD establishing the validity of the method for linearity, accuracy, and precision respectively. The percent contents of the active pharmaceutical ingredients of each sample before degradation ranges from 92.8% to 129.3% resulting in five samples (C, D, I, J, and M) having percent contents that complies with the international pharmacopeia standard (.. Read More»