Original Article
Study of the Effects of Combined Therapy with Sodium Valproate, Peg-interferon and Corticosteroid on Proviral Load of HTLV-1 and the Expression of Rel-A, Creb and IL-1 Genes in Patients with HTLV-1 associated Myelopathy/Tropical Spastic Paraparesis
Author(s):
Hadi Atabati, Hadi Atabati, Davoud Ghaffarian, Reza Farid Hosseini, Reza Boostani, Abdolrahim Rezaei*, Houshang Rafat Panah and Amir Raoofi*
Background and Objective: Human T-Cell Lymphotropic Virus Type I (HTLV-I) is endemic in northeast of Iran. Although chronic inflammation of spinal cord seems to play a major role in the disease pathogenesis, immunomodulatory treatments have not shown significant improvement in disease symptoms. This study was conducted to evaluate the effect of sodium valproate in combination with Peg-Interferon (Peg-IFN) and prednizolone on proviral load and inflammatory factors of patients with HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP). Materials and Methods: In this pilot clinical trial, 10 HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) patients, referred to HTLV- 1 clinic of Qaem Hospital of Mashhad, Iran in 2012, were treated with sodium valproate, Peg-IFN and prednizolone for 6 months. P.. Read More»
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The Annals of Medical and Health Sciences Research is a bi-monthly multidisciplinary medical journal.