Original Article
Assessment of the Effects of IL9, IL9R, IL17A, and IL17F Gene Polymorphisms on Women with Allergic
Rhinitis in Shahrekord, Iran
Author(s):
Fatahi F, Chaleshtori ARS, Ghatreh Samani K, Mousavi SM, Zandi F, Heydari, Hashemzadeh Chaleshtori M, Amiri M* and Khazraee H
Background: The genes encoding IL9, IL9R, IL17A, and IL17F have recently been implicated in the genetic basis of rhinitis and allergy. Aim: The purpose of this study was to assess the association of the single nucleotide polymorphisms (SNPs) of IL9, IL9R, IL17A, and IL17F and potential interaction of these genes with the determination of IgE levels in women with allergic rhinitis (AR) in Shahrekord, Iran. Subjects and Methods: In a case–control study, SNPs from the IL9, IL9R, IL17A, and IL17F were genotyped in 394 random samples including 195 AR patients and 199 normal controls. EnzymeâÂ?Â?linked immunosorbent assay was performed for the determination of serum total IgE levels. The Student’s tâÂ?Â?test was used to compare the differences. The ChiâÂ?Â?square test was performed to compare proportions of cases with different clinical features among cases with different gen.. Read More»
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