Research Article
Evaluation of the Secretion of Nerve Growth Factor by Dental Pulp Fibroblasts that have been Stimulated by Caries Related Bacteria
Author(s):
Rukhsaar Akbar Gulzar*, Ajitha P and Haripriya Subbaiyan
Introduction: During inflammation of pulp, an elevation in the secretion of various inflammatory biomarkers and cytokines by fibroblasts have been observed. Nerve Growth Factor (NGF) is a protein that has been associated with neuropathic and nociceptive pain. Dental pain involves nociceptive pain mechanism due to the presence of A∂ (myelinated) and C (unmyelinated) fibres. Thus, highlighting the probability of the role of NGF signalling pathway in dental pain. The present study was conducted to evaluate the secretion of NGF by pulp fibroblast cells.
Materials & Methods: The human fibroblast cell lines were purchased from American Type Culture Collection (ATCC). All these fibroblasts were cultured in Dulbecco's Modified Eagle Medium (DMEM). A pure culture of test strain of S. mutans ATCC 29212 was inoculated in sterile nutrient broth. .. Read More»
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