Original Article
Assessment Profile of Biomarker Indexes with FHIT Gene Methylation in Oral Epithelium Tissues among Smokers and Non-smokers in Duhok Province, Iraq
Author(s):
Chanar Mousa Sulaiman* and Intisar Salim Pity
Background and objectives: Different pathological and molecular changes can occur in oral epithelium after exposure to cigarette smoking. Management of these changes which may predispose to dysplasia and subsequently invasive cancer depends on the ability to predict malignant transformation like assessment of proliferative index and tumor related genomic markers. Fragile Histidine Triad (FHIT) gene is a tumor suppressor gene that is frequently inactivated by methylation, and this inactivation has been linked to cancer development in many tissues. The present study is aimed to investigate ki67-labeling index, p16 immunoexpression, and the methylation status of the FHIT gene in oral epithelium among smokers. Materials and methods: Tissue samples from 150 oral epithelial were taken from smokers and nonsmokers with different epithelial p.. Read More»
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