Iyiola Sina

Department of Medical Laboratory Science, (Histocytopathology Unit) College of Basic and Health Science, Achievers University, Owo, Ondo State, Nigeria

Publications

• Original Article   
  BAX and BCL-2 Gene Mutation Signature in Benign and Malignant Lesions of the Breast
  Author(s): Ekundina Victor Olukayode*, Awopetu Ayodele Victoria, Oladoye Olawalepelumi Olayinka, Alabi Gloria Oluwagbenro and Iyiola Sina
  
  Background: Apoptosis regulator BAX, also known as bcl-2-like protein 4, is a protein that in humans is encoded by the BAX gene. BAX, a central cell death regulator, is an indispensable gateway to mitochondrial dysfunction and a major pro-apoptotic member of the BCL-2 family proteins that control apoptosis in normal and cancer cells. Dysfunction of apoptosis renders the cancer cell resistant to treatment as well as promotes tumorigenesis. The aim was to study BAX and BCL-2 gene mutations in benign and malignant lesions of the breast. Materials and methods: A case controlled retrospective study was done with a total of 10 formalin fixed and paraffin wax embedded tissue blocks retrieved from pathology archives, amongst these were 5 benign fibroadenoma and 5 m alignant invasive ductal carcin.. Read More»
  10.54608.annalsmedical.2023.86