Original Article
Characteristics of Collagen to Differentiate Fibrous Hyperplasia from Mesenchymal and Mixed Odontogenic Tumors: A Polarized Microscopic Study
Author(s):
Mohamed Nassar M*, Nirmal Ramadoss M, Veeravarmal Veeran, Sunil Paramel M, Kumar Arul T and Parvees Mohamed MY
Context: Mesenchymal odontogenic tumors arise from the remnants of the mesenchymal portion of tooth germ. Central odontogenic fibroma (COF), odontogenic myxoma (OM) and Ameloblastic fibroma (AF) are closely related and show varied clinical presentation and overlapping histopathology. They are differentiated by their collagen quantity, maturity and distribution. Diagnostic difficulties are posed when compared with enlarged dental follicle (EDF) as it closely resembles them. Aim: To analyze the collagen in COF, OM, AF and EDF both quantitatively and qualitatively to choose the best attributes which characterize them. Settings and Design: Polarized microscopy and picro-sirius red staining to visualize every collagen bundle in birefringent state was employed. Material and Methods: 22 tissue se.. Read More»
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