Mahmoud Hosseini

Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Science, Mashhad, Iran

Publications

• Original Article   
  Protection against Brain Tissues Oxidative Damage as a Possible Mechanism for Improving Effects of Soy on Scopolamine-Induced Learning and Memory Impairments in Ovariectomized Rats
  Author(s): Sareh Karimi, Mahmoud Hosseini*, Zahra Mahdian and Beheshteh Babazadeh
  
  Background: Modulatory and antioxidant effects of soy extract on the central nervous system have been reported. Aim: The effects of soy on learning and memory impairments induced by scopolamine and the brain tissues oxidative damage was investigated. Materials and Methods: The ovariectomized rats were divided: (1) Ovariectomized (OVX), (2) Ovariectomized – Scopolamine (OVX-Sco), (3) Ovariectomized -Scopolamine - Soy 20 (OVX-Sco-Soy 20) and (4) Ovariectomized -Scopolamine-Soy 60 (OVX-Sco-Soy 60). Soy extract was administered (20 or 60 mg/kg; i.p.) daily for 6 weeks before training in the passive avoidance (PA) test. Sco (2mg/kg) was injected 30 min after training in the PA test. Results: In PA test, the time latency to enter the dark compartment in OVX- Sco group was higher than OVX g.. Read More»