Original Article
Quantitative Evaluation of Macrophage Expression Using CD68 in Oral Submucous Fibrosis: An Immunohistochemical Study
Author(s):
Pereira T*, Naik S and Tamgadge A
Background: Macrophages are important cells for the innate immunity. Circulating monocytes are attracted to tissues by chemotactic factors and become macrophages under the influence of their microenvironment. Several studies suggested that local and systemic upregulation of fibrogenic cytokines and downregulation of antifibrotic cytokine are central to the pathogenesis of oral submucous fibrosis (OSMF). Currently, there have been no attempts made to elucidate the presence and role of macrophages in OSMF. Aim: Our aim was to study the expression of CD68 in OSMF patients and to investigate the possible correlation of macrophages using CD68 in various histopathological grades of OSMF. Subjects and Methods: A prospective case–control study which included 40 patients was conducted after obtaining informed consent and Ethical Committee clearance. Ten cases were normal control and thir.. Read More»
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The Annals of Medical and Health Sciences Research is a bi-monthly multidisciplinary medical journal.