Original Article
Effect of Methotrexate Therapy on p53 and Bcl2 Expression in Patients with Psoriasis: A Prospective Hospital-Based Cohort Study
Author(s):
Sonali Kalyan, Nadia Shirazi*, Rashmi Jindal and Sohaib Ahmad
Background: Psoriasis is a chronic, relapsing, inflammatory, and hyperproliferative skin disease. The growth of keratinocytes is regulated by a delicate balance between molecules controlling cell survival (such as Bcl2) and cell death (such as p53). The study was conducted to observe the clinical and histopathological effect of Methotrexate on psoriatic lesions. Materials & Methods: The immunohistochemical expression of pro-apoptotic (p53) and anti-apoptotic (Bcl2) proteins was correlated with histomorphological changes (epidermal thickness, munro microabscess, granular layer, lymphocytic infiltrate, blood vessels) in the psoriatic skin. Results: A total of 35 cases of psoriasis were studied. Male predominance was seen and trunk was the initial site of involvement in 40% cases. There was a significant .. Read More»
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The Annals of Medical and Health Sciences Research is a monthly multidisciplinary medical journal.