Thiago Fraga Napoli

Department of Internal Medicine, State Government Employee Medical Assistance Institute (IAMSPE), São Paulo, Brazil

Publications

• Research Article   
  Efficacy of Sibutramine and Topiramate Combination in Weight Loss: Retrospective Cohort Study on Brazilian Adults
  Author(s): Heloisa Harumi Yamamoto*, Thiago Fraga Napoli and João Eduardo Nunes Salles
  
  Introduction: Obesity is a chronic, prevalent, multifactorial disease, stigmatized and linked to multiple long-term complications, which makes the treatment currently available below of the expectations from what is necessary to combat it. Because of this limitation, off-label medications for the treatment of obesity, such as topiramate, have been widely used, in association with on-label medications, such as sibutramine, in order to achieve more effective weight loss. The objective of this study is to compare the effectiveness of the combination of sibutramine and topiramate with sibutramine monotherapy in weight loss in obese adults in regular follow-up. An effective weight loss is expected in the association group, due to complementary mechanisms of act, and antagonistic side effects of drugs, leading to greater weight loss and therapeutic adherence. .. Read More»