Original Article
Re‑Evaluation of the First Phenytoin Paste Healing
Effects on Oral Biopsy Ulcers
Author(s):
Baharvand M, Mortazavi A, Mortazavi H* and Yaseri M
Background: Until now, several formulations of topical phenytoin have been used to promote wound healing. Aim: This study was aimed at reâÃ?Â?Ã?Â?evaluating the effects of a newly formulated phenytoin mucoadhesive paste on wound healing after oral biopsy. Subjects and Methods: In a doubleâÃ?Â?Ã?Â?blind clinical trial, 35 consecutive patients with oral lichenoid or lichen planus lesions were randomized into two groups. After incisional biopsy, patients applied simple, or 1% phenytoin paste at least three times a day (after each meal), for 4 days. They were evaluated every other day for size of wound closure, severity of pain, and diameter of the inflammatory halo. This study was approved by Medical Ethics committee of Shahid Beheshti University of Medical Sciences, Tehran, Iran. Statistical analysis was performed using Mann–Whitney U test and Ordinal Logistic Regressi.. Read More»
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