Research Article
Neoadjuvant Chemotherapy plus Plus Volumetricmodulated
Arc Therapy for the Treatment of Loco
Regionally Advanced Nasopharyngeal Carcinoma: A
Retrospective Study
Author(s):
Rolina Al-Wassia*, Ahmed Mohamed Ameen M Ahmed, Mohammed Sheikh Al-Amoodi, Zuhair Natto, Osama Yousof, Azhar Nawaz, Ahmed AHussein, Firas R Abisheffah, Zaheeda Mulla, Shadi Al-Khayyat and Reyad Dada
Background & Purpose: Nasopharyngeal carcinoma is attributed for 33% of head and neck malignancy in Saudi Arabia. In treatment of NPC, chemoradiotherapy is used as a modality of choice. The present study aims to determine the effect of Neoadjuvant Chemotherapy (NACT) in Local Control (LC) and Overall Survival (OS) of NPC patients treated in King Faisal Hospital and Research Center (KFSHRC), Jeddah, Saudi Arabia. Materials & Methods: Patients treated for NPC were retrospectively studied. Demographic characteristics and chemotherapy data were gathered and analyzed. Kaplan-Meier product-survival estimates and multivariate analysis were conducted to describe and determine the effect of NACT plus CCT in LC and OS. Results: Seventyseven patients with loco regional advanced NPC were studied. Majority of the patients had Stage 3 NPC (.. Read More»
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